Arbetsbeskrivning

RaySearch develops innovative software solutions to improve cancer care. About 1000 clinics in more than 40 countries use RaySearch software to improve treatments and quality of life for patients. RaySearch was founded in 2000 and is listed on Nasdaq Stockholm. The headquarters is located in Stockholm, with subsidiaries in the US, Europe and Asia - Pacific. Today we are more than 400 employees with a common vision of improving cancer care with innovative software. Our great staff is crucial for our success and we offer a fantastic working environment in modern offices, flexibility and good opportunities for development. We believe in equal opportunities, value diversity and work actively to prevent discrimination. We invite you to apply for a doctoral candidate (DC) position in the European Doctoral Network RAPTORplus. The network brings together 16 leading partners from clinics, academia, and industry to train 18 PhD students. One position is based at RaySearch HQ in Stockholm, focusing on robust optimization using radiobiological models and functional imaging. For more information, visit: • The RAPTORplus consortium: https://raptor-consortium.com • DC17 project at RaySearch: https://raptor-consortium.com/projects/raptorplus-project-dc17 Application Please submit your application through the central application website: https://indico.psi.ch/event/18261/ Please note: MSCA mobility rules apply. You must not have lived or had your main activity (work, studies, etc.) in Sweden for more than 12 months during the 36 months before the recruitment date. Description of Doctoral Candidate Project DC17 Radiotherapy is a fundamental modality in oncology treatment, typically delivered over multiple fractions across several weeks. Throughout the treatment course, patients may exhibit substantial anatomical modifications (such as tumour regression or weight loss) as well as biological and functional changes within both malignant and healthy tissues. These dynamic variations can compromise the precision and therapeutic efficacy of radiation delivery, making the initial treatment plan suboptimal and necessitating adaptive strategies to maintain clinical outcomes. Current treatment planning and adaptation strategies in radiotherapy predominantly focus on the physical dose distribution delivered to the patient. While effective to some extent, these approaches offer limited personalization and frequently neglect individual biological variability, such as tumour response dynamics and normal tissue sensitivity. This project seeks to enhance both the efficacy and personalization of radiotherapy by integrating biological modelling with conventional dose-based planning. Specifically, it will focus on developing methodologies that leverage biological information and imaging biomarkers for optimizing the initial treatment plan and guide adaptive strategies throughout the treatment course. The project has three main components: 1. Robust radiobiological optimization – Improving initial treatment planning by considering not only dose but also radiobiological models that predicts how tumours and healthy tissues respond to radiation, while accounting for underlying uncertainties. 2. Functional imaging integration – Using advanced imaging (e.g., PET/fMRI combined with CT or other anatomical imaging) to monitor both anatomical changes and tissue responses, enabling adaptation of the radiotherapy treatment based on both anatomical and biological indicators. 3. Biologically guided adaptive planning – Combining these approaches into a research prototype of a commercial treatment planning system for individualised initial treatment planning and adaptive treatments, accounting for underlying geometrical and biological uncertainties. By incorporating biological and imaging data, this project aims to enable more personalized and adaptive radiotherapy treatments, moving beyond traditional dose-based methods. The successful candidate will be employed at RaySearch Laboratories under the supervision of Jakob Ödén and Albin Fredriksson and will join the Research Department, which currently comprises 29 members. The candidate will also be enrolled in the Ph.D. program in Medical Radiation Physics at Stockholm University and become part of its research group under the academic supervision of Prof. Iuliana Toma-Dasu. This unique collaboration offers a diverse and stimulating research environment, with access to offices and resources at both institutions, located in Hagastaden, Stockholm’s Life Science Hub, within walking distance of each other. Your profile Requirements: • MSc who has excelled in a relevant field: applied mathematics, biomedical engineering, computer science, physics or similar discipline • Knowledge and interest in programming and applied mathematics • Excellent communication skills in English Meriting: • Experience in radiotherapy and/or functional imaging • Experience in mathematical optimization and/or algorithms • Programming skills in C# or C++ Our Culture Culture at RaySearch is the driving force behind our organization, where everything we do is driven by a shared passion for innovation and the fight against cancer. Our dedication is reflected in our ability to deliver exceptional results, pay close attention to detail, and consistently go the extra mile. Our employees stand out as experts in their field, driven by a relentless focus on solving problems - no matter how complex. At RaySearch, we take pride in leading the way in cancer treatment, leveraging cutting-edge technology to develop innovative solutions that make a real difference in patient care. Our Offer At RaySearch, we offer a diverse and inclusive work environment that fosters openness, sincerity, and collaboration. Located in Hagastaden, Stockholm’s Life Science Hub, our modern and creative workspace features an in-house gym, yoga, and social activities such as ping pong, table football, and regular after-work events. Our bistro serves a high-quality lunch buffet, and we offer morning and afternoon fika every day. From our rooftop terrace, you can enjoy a stunning 360-degree view of Stockholm. In addition, we provide a competitive compensation and benefits package including an attractive pension scheme, parental pay top-up, wellness allowance, private health insurance and other comprehensive insurance coverage, 30 days of paid vacation, Swedish language classes, and more.