Arbetsbeskrivning

Responsibilities

Perform research to help elucidate drug mechanism-of-action and resistance mechanisms through experimental design, execution, and data interpretation.

Perform research to design, screen and analyze data to evaluate drug candidates in our early discovery pipeline.

Develop novel mechanism-of-action cell-based models that closely mimic human cancer to enable biomarker discovery, answer mechanistic questions and validate biomarkers for therapeutic targets.

Participate in analysis and evaluation of large phospho-proteomic data sets from drug profiling studies of both cell lines and tissue samples through signal transduction pathway-based analyses.

Contribute as a member of a diverse and motivated team of researchers across Oncology disciplines and key internal and external collaborators.

Read and critically evaluate literature to keep abreast of scientific and technological advances.

Lead or contribute to scientific publications.

Qualifications

· PhD in cell biology, cancer biology or other related scientific discipline with at least 5 years of relevant experience in academia or industry.

· Demonstrated expertise in cancer biology, signal transduction, oncogenic signaling pathways, and/or translational biomarker research required.

· Excellent written and interpersonal communication skills with the ability to interact effectively with internal and external colleagues are required.

· Ability to troubleshoot effectively and constructively implement solutions within the broader teams.

· Proven track record of quality research and deep scientific knowledge as evidenced by high impact, peer reviewed publications highly preferred.

Knowledge and hands-on experience in several of the following areas are highly desirable:

· Molecular and Cellular Biology: Western blotting, ELISA, immunofluorescence

· Expertise related to DNA damage response (DDR) signaling, cell cycle regulation and/or DNA replication biology.

· Cell-based assays: tissue culture, cell proliferation and viability assays, reporter assays, flow cytometry and cell cycle analysis, transfection, assays examining DNA damage and DNA replication stress response pathways.

· Demonstrated expertise in development/optimization of in vitro/ex vivo

· Experience in microscopy.

· Proficiency in data collection/analysis/documentation of all study results in the form of electronic lab notebook reports.