Arbetsbeskrivning

Are you an analytical chemist with experience in automation? If so, we have an exciting opportunity for you. AstraZeneca is seeking a Senior Scientist in Automation and Analytical chemistry to join our Small Molecule Preformulation team within the Advanced Drug Delivery (ADD) function. This role is based in Gothenburg, Sweden and is part of our Pharmaceutical Sciences division. Accountabilities: Pharmaceutical Sciences at AstraZeneca delivers the therapies of the future through scientific leadership in drug delivery, design of synthetic routes, and manufacturing of Active Pharmaceutical Ingredients (API) and drug products. Our portfolio of projects spans traditional small molecules, peptides, oligonucleotides to RNA based therapeutics across AstraZeneca's therapy areas. Advanced Drug Delivery (ADD) resides within Pharmaceutical Sciences with a mission to provide novel products to AstraZeneca's clinical pipeline. As an Analytical and Automation Senior Scientist you will drive lab efficiency and innovation by automating workflows and applying analytical expertise in the pre-clinical development phase. You will focus on various small molecule projects and develop suitable analytical techniques to risk assess formulation development for PK, PK/PD studies, and toxicology studies, but also to influence suitable choice of compounds for further development. You are expected to develop and integrate automation solutions to transform manual laboratory operations, focusing specifically on analytical tasks in the pre-clinical phase. As an analytical scientist you are anticipated to perform and evaluate assessments looking for potential degradation pathways with the use of MS data. You will develop new stability indicating methods for our pre-clinical formulations and set up methods for the validation of the quality of our pre-clinical formulations. You will also participate in scientific initiatives and technical improvement activities within the department to increase scientific knowledge and simplify our data generation and handling. You will work as a member of pharmaceutical project teams, and in close collaboration with other analysts, formulators, solid state, biopharmaceutics experts at AstraZeneca. You will independently support drug projects from the first in vivo studies to candidate drug nomination. Key Responsibilities: * Develop and integrate automation solutions, focusing on liquid handling and sample preparation and injection systems, such as TECAN and CTC PAL, to streamline laboratory operations. * Transition manual processes to automated workflows, ensuring efficiency and precision. * Collaborate cross-functionally to enhance lab capabilities with new technologies. * Conduct comprehensive analyses using advanced chromatographic techniques, with a focus on method development and stability studies and understanding. * Provide analytical support to drug projects from initial studies to candidate drug nomination, influencing compound selection for further development. * Troubleshoot and maintain automated systems, ensuring optimal performance and reliability. * Engage in scientific initiatives to elevate knowledge and improve data handling within the department. Essential Skills/Experience: * PhD or MSc with over 5 years' experience in a relevant scientific discipline (organic chemistry, analytical chemistry, pharmaceutical technology). * Excel in a collaborative team setting, demonstrated ability to take personal responsibility for contributions and impact. * Proven experience in laboratory automation, particularly using TECAN and CTC PAL systems. * Strong expertise in analytical chemistry techniques, including chromatography and stability assessments. * Basic knowledge of physical and organic chemistry for designing stable pharmaceutical formulations. * Proficiency in laboratory software and automation tools, with a strong understanding of GLP/GMP as well as SHE practices. * Ability to communicate complex scientific concepts effectively, both orally and in writing. Desirable Skills/Experience: * Experience in pharmaceutical product development in the pre-clinical phase * Experience and knowledge in HRMS and MS/MS * Experience using Empower software for chromatographic evaluation. * Innovative mindset with a drive for scientific excellence and continuous improvement. * Excellent stakeholder management skills and the ability to simplify complex ideas. * Industry experience in problem-solving and leading scientific projects independently. ​ To be a successful candidate for the Automation and Analytical Chemistry Specialist position, you should have experience in analytical chemistry, organic chemistry, pharmacy or similar, with focus on automation. You should be passionate about transitioning manual processes into automated workflows, focusing specifically on analytical tasks. You will also need effective communication and planning skills, balanced with the ability to work independently. An intense sense of responsibility, teamwork capability, and delivery-focused attitude are crucial for this senior scientist role. So, what's next? Are you ready to bring innovative ideas and fresh thinking to the table? Then you might be the person we are looking for! Please submit your application no later than 3 June 2025. Please note that applications must include your current CV, and a covering letter which presents your key areas of strength and why you should be considered for the role.